Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

Cancer vaccines often fail to generate clinically relevant effects. Here, the authors generate a nanosized cytomembrane vaccine based on fusion between dendritic cells and cancer cells, and show them to activate anti-tumor immune responses via their antigen presenting and T-cell activating functions...

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Main Authors:	Wen-Long Liu, Mei-Zhen Zou, Tao Liu, Jin-Yue Zeng, Xue Li, Wu-Yang Yu, Chu-Xin Li, Jing-Jie Ye, Wen Song, Jun Feng, Xian-Zheng Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11157-1

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spelling	doaj-67ae9c77ce0a4c3384f5b7c2f11709b82021-05-11T12:21:07ZengNature Publishing GroupNature Communications2041-17232019-07-0110111210.1038/s41467-019-11157-1Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cellsWen-Long Liu0Mei-Zhen Zou1Tao Liu2Jin-Yue Zeng3Xue Li4Wu-Yang Yu5Chu-Xin Li6Jing-Jie Ye7Wen Song8Jun Feng9Xian-Zheng Zhang10Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityThe Institute for Advanced Studies, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan UniversityCancer vaccines often fail to generate clinically relevant effects. Here, the authors generate a nanosized cytomembrane vaccine based on fusion between dendritic cells and cancer cells, and show them to activate anti-tumor immune responses via their antigen presenting and T-cell activating functions.https://doi.org/10.1038/s41467-019-11157-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wen-Long Liu Mei-Zhen Zou Tao Liu Jin-Yue Zeng Xue Li Wu-Yang Yu Chu-Xin Li Jing-Jie Ye Wen Song Jun Feng Xian-Zheng Zhang
spellingShingle	Wen-Long Liu Mei-Zhen Zou Tao Liu Jin-Yue Zeng Xue Li Wu-Yang Yu Chu-Xin Li Jing-Jie Ye Wen Song Jun Feng Xian-Zheng Zhang Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells Nature Communications
author_facet	Wen-Long Liu Mei-Zhen Zou Tao Liu Jin-Yue Zeng Xue Li Wu-Yang Yu Chu-Xin Li Jing-Jie Ye Wen Song Jun Feng Xian-Zheng Zhang
author_sort	Wen-Long Liu
title	Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
title_short	Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
title_full	Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
title_fullStr	Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
title_full_unstemmed	Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
title_sort	cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	Cancer vaccines often fail to generate clinically relevant effects. Here, the authors generate a nanosized cytomembrane vaccine based on fusion between dendritic cells and cancer cells, and show them to activate anti-tumor immune responses via their antigen presenting and T-cell activating functions.
url	https://doi.org/10.1038/s41467-019-11157-1
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Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

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