In vitro Activity and Heteroresistance of Omadacycline Against Clinical Staphylococcus aureus Isolates From China Reveal the Impact of Omadacycline Susceptibility by Branched-Chain Amino Acid Transport System II Carrier Protein, Na/Pi Cotransporter Family Protein, and Fibronectin-Binding Protein

In vitro Activity and Heteroresistance of Omadacycline Against Clinical Staphylococcus aureus Isolates From China Reveal the Impact of Omadacycline Susceptibility by Branched-Chain Amino Acid Transport System II Carrier Protein, Na/Pi Cotransporter Family Protein, and Fibronectin-Binding Protein

Omadacycline (Omad), a new tetracycline (Tet)-class broad-spectrum aminomethylcycline, has been reported to exhibit excellent potency against Gram-positive bacteria, including Staphylococcus aureus and Enterococci. The aim of this study was to evaluate the in vitro activity and heteroresistance char...

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Bibliographic Details
Main Authors: Bing Bai, Zhiwei Lin, Zhangya Pu, Guangjian Xu, Fan Zhang, Zhong Chen, Xiang Sun, Jinxin Zheng, Peiyu Li, Qiwen Deng, Zhijian Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Microbiology
Subjects:
omadacycline
Staphylococcus aureus
antimicrobial activity
multilocus sequence typing
tetracycline specific resistance genes
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02546/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02546/full

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