Inhibition of Fatty Acid Synthesis Aggravates Brain Injury, Reduces Blood-Brain Barrier Integrity and Impairs Neurological Recovery in a Murine Stroke Model

Inhibition of Fatty Acid Synthesis Aggravates Brain Injury, Reduces Blood-Brain Barrier Integrity and Impairs Neurological Recovery in a Murine Stroke Model

Inhibition of fatty acid synthesis (FAS) stimulates tumor cell death and reduces angiogenesis. When SH-SY5Y cells or primary neurons are exposed to hypoxia only, inhibition of FAS yields significantly enhanced cell injury. The pathophysiology of stroke, however, is not only restricted to hypoxia but...

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Bibliographic Details
Main Authors: Lisa Janssen, Xiaoyu Ai, Xuan Zheng, Wei Wei, Ahmet B. Caglayan, Ertugrul Kilic, Ya-chao Wang, Dirk M. Hermann, Vivek Venkataramani, Mathias Bähr, Thorsten R. Doeppner
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
blood-brain barrier
cerebral ischemia
fatty acid synthesis
hypoxia
neuroprotection
reduction potential
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.733973/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.733973/full

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