The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

Abstract Background Previous study demonstrated that extracellular ATP could promote cell migration and invasion in multiple human cancers. Till now, the pro-invasive mechanisms of ATP and P2RX6, a preferred receptor for ATP, are still poorly studied in RCC. Methods Bioinformatics analysis was perfo...

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Bibliographic Details
Main Authors: Dongkui Gong, Jin Zhang, Yonghui Chen, Yunfei Xu, Junjie Ma, Guanghui Hu, Yiran Huang, Junhua Zheng, Wei Zhai, Wei Xue
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Renal cell carcinoma
P2RX6
m6A
Ca2+
p-ERK1/2/MMP9
Online Access:http://link.springer.com/article/10.1186/s13046-019-1223-y

Internet

http://link.springer.com/article/10.1186/s13046-019-1223-y

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