Hepatic 7α-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs

Cholesterol 7α-hydroxylase activity was assayed in liver microsomes from guinea pigs supplemented with ascorbate and from guinea pigs in a state of ascorbate deficiency. A mass fragmentographic method was used by which the 7α-hydroxylation of endogenous cholesterol could be measured. The 7α-hydroxyl...

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Bibliographic Details
Main Authors: I Björkhem, A Kallner
Format: Article
Language:English
Published: Elsevier 1976-07-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520349191