Secreted protein acidic and rich in cysteine (SPARC) suppresses angiogenesis by down-regulating the expression of VEGF and MMP-7 in gastric cancer.

Secreted protein acidic and rich in cysteine (SPARC) suppresses angiogenesis by down-regulating the expression of VEGF and MMP-7 in gastric cancer.

BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein that functions to inhibit angiogenesis, proliferation, and invasion in different types of cancer. The ability of SPARC to modulate neovascularisation is believed to be mediated in part by its ability to modulate the e...

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Bibliographic Details
Main Authors: Jun-Ling Zhang, Guo-Wei Chen, Yu-Cun Liu, Peng-Yuan Wang, Xin Wang, Yuan-Lian Wan, Jing Zhu, Hong-Qiao Gao, Jie Yin, Wei Wang, Mao-Lin Tian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3434168?pdf=render

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http://europepmc.org/articles/PMC3434168?pdf=render

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