Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation

Abstract Interleukin (IL)-6 is a pleiotropic cytokine involved in the regulation of hematological and immune responses. IL-6 is secreted chiefly by stromal cells, but little is known about its precise role in the homeostasis of human mesenchymal stromal cells (hMSCs) and the role it may play in hMSC...

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Bibliographic Details
Main Authors: Akaitz Dorronsoro, Valérie Lang, Izaskun Ferrin, Jon Fernández-Rueda, Lorea Zabaleta, Estibaliz Pérez-Ruiz, Pilar Sepúlveda, César Trigueros
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78864-4