Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction

Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction

Our previous studies demonstrated that the psychostimulant methamphetamine (MA) and the human immunodeficiency virus-1 (HIV-1) protein Tat interacted to cause enhanced dopaminergic neurotoxicity. The present study examined whether tumor necrosis factor-alpha (TNF-α) mediates the interaction between...

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Bibliographic Details
Main Authors: Shaji Theodore, Wayne A. Cass, Avindra Nath, Joseph Steiner, Kristie Young, William F. Maragos
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
AIDS
Basal ganglia
Cytokines
Dopamine
Drug abuse
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001252

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http://www.sciencedirect.com/science/article/pii/S0969996106001252

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