Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

Abstract Background Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. This chronic liver disease has a poorly understood etiology and demonstrates sexual dimorphisms. We aim to...

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Bibliographic Details
Main Authors: Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon T Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons J Lusis, Xia Yang
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Biology of Sex Differences
Subjects:
Non-alcoholic fatty liver disease (NAFLD)
Sexual dimorphism
Multi-omics integration
Key regulator genes
Bayesian networks
Coexpression networks
Online Access:http://link.springer.com/article/10.1186/s13293-018-0205-7

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http://link.springer.com/article/10.1186/s13293-018-0205-7

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