Fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells

Fungal pyrrolidine-containing metabolites inhibit alkaline phosphatase activity in bone morphogenetic protein-stimulated myoblastoma cells

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant congenital disorder characterized by progressive heterotopic ossification in muscle tissues. A constitutively activated mutation of a bone morphogenetic protein (BMP) receptor, ALK2, has been identified in patients with FOP. We...

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Bibliographic Details
Main Authors: Takashi Fukuda, Ryuji Uchida, Hiroyo Inoue, Satoshi Ohte, Hiroyuki Yamazaki, Daisuke Matsuda, Takenobu Katagiri, Hiroshi Tomoda
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lucilactaenes
Fungal metabolites
C2C12 myoblasts
Fibrodysplasia ossificans progressiva
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511001134

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http://www.sciencedirect.com/science/article/pii/S2211383511001134

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