Sphingosine 1-Phosphate Receptor 1 as a Useful Target for Treatment of Multiple Sclerosis

Sphingosine 1-Phosphate Receptor 1 as a Useful Target for Treatment of Multiple Sclerosis

Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, is generated from sphingosine by sphingosine kinases and binds five known cell surface receptors. S1P receptor 1 (S1P<sub>1</sub>) plays an essential role in lymphocyte egress from secondary lymphoid organs (SLO)...

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Bibliographic Details
Main Authors: Kunitomo Adachi, Kenji Chiba
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:Pharmaceuticals
Subjects:
sphingosine 1-phasphate (S1P)
S1P receptor 1 (S1P<sub>1</sub>)
fingolimod (FTY720)
lymphocyte egress
immunomodulator
experimental autoimmune encephalomyelitis (EAE)
multiple sclerosis (MS)
therapy
Online Access:http://www.mdpi.com/1424-8247/5/5/514

Internet

http://www.mdpi.com/1424-8247/5/5/514

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