Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

Although the pathogenic mechanisms of Parkinson's disease (PD) remain unclear, ample empirical evidence suggests that oxidative stress is involved in the pathogenesis of this disease. The nuclear factor E2-related factor 2 (Nrf2) is known to activate several antioxidant response element (ARE)-d...

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Bibliographic Details
Main Authors: Xingfang Guo, Chao Han, Kai Ma, Yun Xia, Fang Wan, Sijia Yin, Liang Kou, Yadi Sun, Jiawei Wu, Junjie Hu, Jinsha Huang, Nian Xiong, Tao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neurology
Subjects:
Parkinson's disease
hydralazine
neuroprotection
Nrf2-ARE signaling pathway
MPTP
MPP+
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00271/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00271/full

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