Regulation of the Spontaneous Augmentation of NaV1.9 in Mouse Dorsal Root Ganglion Neurons: Effect of PKA and PKC Pathways

Regulation of the Spontaneous Augmentation of NaV1.9 in Mouse Dorsal Root Ganglion Neurons: Effect of PKA and PKC Pathways

Sensory neurons in the dorsal root ganglion express two kinds of tetrodotoxin resistant (TTX-R) isoforms of voltage-gated sodium channels, NaV1.8 and NaV1.9. These isoforms play key roles in the pathophysiology of chronic pain. Of special interest is NaV1.9: our previous studies revealed a unique pr...

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Bibliographic Details
Main Authors: Nobukuni Ogata, Noriko Uryu, Taixing Zheng, Jun-ichi Kakimura
Format: Article
Language:English
Published: MDPI AG 2010-03-01
Series:Marine Drugs
Subjects:
Na+ channel
tetrodotoxin
dorsal root ganglion
patch clamp
PKA
PKC
Online Access:http://www.mdpi.com/1660-3397/8/3/728/

Internet

http://www.mdpi.com/1660-3397/8/3/728/

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