"TOF2H": A precision toolbox for rapid, high density/high coverage hydrogen-deuterium exchange mass spectrometry via an LC-MALDI approach, covering the data pipeline from spectral acquisition to HDX rate analysis

<p>Abstract</p> <p>Background</p> <p>Protein-amide proton hydrogen-deuterium exchange (HDX) is used to investigate protein conformation, conformational changes and surface binding sites for other molecules. To our knowledge, software tools to automate data processing an...

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Bibliographic Details
Main Authors: Koter Marek D, Chou Wayne, Pun Elroy, Nikamanon Pornpat, Gershon Paul D
Format: Article
Language:English
Published: BMC 2008-09-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/9/387