Cystic fibrosis: model of pathogenesis based on the apical membrane potential

A simple model of cystic fibrosis (CF) is proposed, based on the apical membrane (ApM) potential. The ApM of epithelial cells is highly permeable to sodium and activation of CFTRs makes it permeable to chloride. Calculated ApM potentials of cells with activated cystic fibrosis transmembrane conducta...

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Bibliographic Details
Main Authors: Beatrica Kurbel, Saša Rapan, Sven Kurbel
Format: Article
Language:English
Published: Medical Association of Zenica-Doboj Canton 2015-02-01
Series:Medicinski Glasnik
Subjects:
AE1
Online Access:http://www.ljkzedo.ba/sites/default/files/Glasnik/12-01-feb2015/01%20Kurbel.pdf