Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies

Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies

Backbone macrocyclic structures are often found in diverse bioactive peptides and contribute to greater conformational rigidity, peptidase resistance, and potential membrane permeability compared to their linear counterparts. Therefore, such peptide scaffolds are an attractive platform for drug-disc...

Full description

Bibliographic Details
Main Authors: Koki Shinbara, Wenyu Liu, Renier Herman Pieter van Neer, Takayuki Katoh, Hiroaki Suga
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Chemistry
Subjects:
non-proteinogenic amino acid
backbone macrocyclic peptide
enzymatic peptide backbone cyclization
peptide library
OBOC screening
SICLOPPS
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00447/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00447/full

Similar Items