Broad cross-reactive epitopes of the H5N1 influenza virus identified by murine antibodies against the A/Vietnam/1194/2004 hemagglutinin.

There is an urgent need for a rapid diagnostic system to detect the H5 subtype of the influenza A virus. We previously developed monoclonal antibodies (mAbs) against the H5 hemagglutinin (HA) for use in a rapid diagnostic kit. In this study, we determined the epitopes of the anti-H5 HA murine mAbs O...

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Main Authors: Mie Kobayashi-Ishihara, Hitoshi Takahashi, Kazuo Ohnishi, Kengo Nishimura, Kazutaka Terahara, Manabu Ato, Shigeyuki Itamura, Tsutomu Kageyama, Yasuko Tsunetsugu-Yokota
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4063728?pdf=render