The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure

The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure

Abstract Background Allele-specific DNA methylation (ASM) describes genomic loci that maintain CpG methylation at only one inherited allele rather than having coordinated methylation across both alleles. The most prominent of these regions are germline ASMs (gASMs) that control the expression of imp...

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Bibliographic Details
Main Authors: Dana M. Freeman, Dan Lou, Yanqiang Li, Suzanne N. Martos, Zhibin Wang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Allele-specific methylation
Rotenone
Parkinson’s disease
Neurotoxicity
Online Access:http://link.springer.com/article/10.1186/s13072-020-00338-8

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http://link.springer.com/article/10.1186/s13072-020-00338-8

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