Targeted Delivery of GP5 Antigen of PRRSV to M Cells Enhances the Antigen-Specific Systemic and Mucosal Immune Responses

Targeted Delivery of GP5 Antigen of PRRSV to M Cells Enhances the Antigen-Specific Systemic and Mucosal Immune Responses

Efficient delivery of antigens through oral immunization is a first and critical step for successful induction of mucosal immunity, which can provide protection against pathogens invading the mucosa. Membranous/microfold cells (M cells) within the mucosa can transcytose internalized antigen without...

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Bibliographic Details
Main Authors: Luping Du, Zhengyu Yu, Fengjiao Pang, Xiangwei Xu, Aihua Mao, Wanzhe Yuan, Kongwang He, Bin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
PRRSV
PLGA
M cells
DNA vaccine
immune response
delivery system
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00007/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2018.00007/full

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