Preparation and Physicochemical Properties of Vinblastine Microparticles by Supercritical Antisolvent Process

Preparation and Physicochemical Properties of Vinblastine Microparticles by Supercritical Antisolvent Process

The objective of the study was to prepare vinblastine microparticles by supercritical antisolvent process using N-methyl-2-pyrrolidone as solvent and carbon dioxide as antisolvent and evaluate its physicochemical properties. The effects of four process variables, pressure, temperature, drug concentr...

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Bibliographic Details
Main Authors: Yuliang Ma, Qi Lu, Xiaonan Zhang, Xiaoqiang Chen, Yuangang Zu, Xiuhua Zhao, Lei Yang
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:International Journal of Molecular Sciences
Subjects:
vinblastine
supercritical antisolvent
micronization
physicochemical property
Catharanthus roseus
Online Access:http://www.mdpi.com/1422-0067/13/10/12598

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http://www.mdpi.com/1422-0067/13/10/12598

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