Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-l-lysine dendrimer as a gene delivery system

Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-l-lysine dendrimer as a gene delivery system

Antisense oligodeoxynucleotide (ASODN) can directly interfere a series of biological events of the target RNA derived from tumor cells through Watson-Crick base pairing, in turn, plays antitumor therapeutic roles. In the study, a novel HIF-1α ASODN-loaded nanocomposite was formulated to efficiently...

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Bibliographic Details
Main Authors: Jianmin Shen, Jing Chen, Jingbo Ma, Linlan Fan, Xiaoli Zhang, Ting Yue, Yaping Yan, Yuhang Zhang
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Antisense oligodeoxynucleotide (ASODN)
Gene delivery
Dendrigraft poly-L-lysines (DGL)
Lysosomal escape
Tumor targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087619308839

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http://www.sciencedirect.com/science/article/pii/S1818087619308839

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