Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

Abstract Background Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade. Methods We examined the molecular and functional effects of sin...

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Bibliographic Details
Main Authors: Anais Del Curatolo, Fabiana Conciatori, Ursula Cesta Incani, Chiara Bazzichetto, Italia Falcone, Vincenzo Corbo, Sabrina D’Agosto, Adriana Eramo, Giovanni Sette, Isabella Sperduti, Teresa De Luca, Mirko Marabese, Senji Shirasawa, Ruggero De Maria, Aldo Scarpa, Massimo Broggini, Donatella Del Bufalo, Francesco Cognetti, Michele Milella, Ludovica Ciuffreda
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
MAPK
BRAF
MEK
Combination therapy
Paradoxical effect
Online Access:http://link.springer.com/article/10.1186/s13046-018-0820-5

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http://link.springer.com/article/10.1186/s13046-018-0820-5

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