Identification and Characterization of the Copy Number Dosage-Sensitive Genes in Colorectal Cancer

Identification and Characterization of the Copy Number Dosage-Sensitive Genes in Colorectal Cancer

Dosage effect is one of the common mechanisms of somatic copy number alteration in the development of colorectal cancer, yet the roles of dosage-sensitive genes (DSGs) in colorectal cancer (CRC) remain to be characterized more deeply. In this study, we developed a five-step pipeline to identify DSGs...

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Bibliographic Details
Main Authors: Zhiqiang Chang, Xinxin Liu, Wenyuan Zhao, Yan Xu
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
colorectal cancer
copy number
dosage sensitive
driver gene
drug target
cancer immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301443

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http://www.sciencedirect.com/science/article/pii/S2329050120301443

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