Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

Recurrent, metastatic prostate cancer continues to be a leading cause of cancer-death in men. The androgen receptor (AR) is a modular, ligand-inducible transcription factor that regulates the expression of genes that can drive the progression of this disease, and as a consequence, this receptor is a...

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Bibliographic Details
Main Authors: Paul S. Rennie, Artem Cherkasov, Nada Lallous, Kush Dalal
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:International Journal of Molecular Sciences
Subjects:
androgen receptor
prostate cancer
castration resistance
anti-androgens
protein structure
structure-based drug design
Online Access:http://www.mdpi.com/1422-0067/14/6/12496

Internet

http://www.mdpi.com/1422-0067/14/6/12496

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