A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma

A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma

Abstract Currently, preclinical testing of therapies for hepatoblastoma (HB) is limited to subcutaneous and intrasplenic xenograft models that do not recapitulate the hepatic tumors seen in patients. We hypothesized that injection of HB cell lines into the livers of mice would result in liver tumors...

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Bibliographic Details
Main Authors: Sarah E. Woodfield, Yan Shi, Roma H. Patel, Jingling Jin, Angela Major, Stephen F. Sarabia, Zbigniew Starosolski, Barry Zorman, Siddharth S. Gupta, Zhenghu Chen, Aryana M. Ibarra, Karl-Dimiter Bissig, Ketan B. Ghaghada, Pavel Sumazin, Dolores López-Terrada, Sanjeev A. Vasudevan
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-17665-8

Internet

https://doi.org/10.1038/s41598-017-17665-8

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