Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Objective: Structurally-improved GIP analogs were developed to determine precisely whether GIP receptor (GIPR) agonism or antagonism lowers body weight in obese mice. Methods: A series of peptide-based GIP analogs, including structurally diverse agonists and a long-acting antagonist, were generated...

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Bibliographic Details
Main Authors: Piotr A. Mroz, Brian Finan, Vasily Gelfanov, Bin Yang, Matthias H. Tschöp, Richard D. DiMarchi, Diego Perez-Tilve
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818311025

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