Autocrine role of angiopoietins during megakaryocytic differentiation.

The tyrosine kinase Tie-2 and its ligands Angiopoietins (Angs) transduce critical signals for angiogenesis in endothelial cells. This receptor and Ang-1 are coexpressed in hematopoietic stem cells and in a subset of megakaryocytes, though a possible role of angiopoietins in megakaryocytic differenti...

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Bibliographic Details
Main Authors: Ernestina Saulle, Raffaella Guerriero, Alessia Petronelli, Elena Coppotelli, Marco Gabbianelli, Ornella Morsilli, Isabella Spinello, Elvira Pelosi, Germana Castelli, Ugo Testa, Simona Coppola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3391299?pdf=render