Latent TGF-β Activation Is a Hallmark of the Tenascin Family

Latent TGF-β Activation Is a Hallmark of the Tenascin Family

Transforming growth factor-β (TGF-β) isoforms are secreted as inactive complexes formed through non-covalent interactions between bioactive TGF-β entities and their N-terminal pro-domains called latency-associated peptides (LAP). Extracellular activation of latent TGF-β within this complex is a cruc...

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Bibliographic Details
Main Authors: Alexandre Aubert, Perrine Mercier-Gouy, Stéphanie Aguero, Laurent Berthier, Sophie Liot, Laura Prigent, Lindsay B. Alcaraz, Bernard Verrier, Raphaël Terreux, Catherine Moali, Elise Lambert, Ulrich Valcourt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
tenascins
transforming growth factor (TGF)-β
latent TGF-β activation
tissue homeostasis
tumor microenvironment
immune cell modulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.613438/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.613438/full

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