Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisin...

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Bibliographic Details
Main Authors: Nicolli Bellotti de Souza, Anna Caroline Campos Aguiar, Alane Cabral de Oliveira, Siden Top, Pascal Pigeon, Gérard Jaouen, Marilia Oliveira Fonseca Goulart, Antoniana Ursine Krettli
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015-01-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Plasmodium falciparum
metallodrug activity
ruthenocifens
ferrocifens
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015005025102&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015005025102&lng=en&tlng=en

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