BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19

BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19

BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2,...

Full description

Bibliographic Details
Main Authors: Rui-Ru Ji, Yajin Qu, Hua Zhu, Yumei Yang, Annette B. Vogel, Ugur Sahin, Chuan Qin, Aimin Hui
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Vaccines
Subjects:
SARS-CoV-2
COVID-19
mRNA vaccine
efficacy
immunogenicity
challenge study
Online Access:https://www.mdpi.com/2076-393X/9/4/324
id doaj-6630e5dcbab3497d9e9d10d9b39c7a4c
record_format Article
spelling doaj-6630e5dcbab3497d9e9d10d9b39c7a4c2021-04-01T23:01:50ZengMDPI AGVaccines2076-393X2021-04-01932432410.3390/vaccines9040324BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19Rui-Ru Ji0Yajin Qu1Hua Zhu2Yumei Yang3Annette B. Vogel4Ugur Sahin5Chuan Qin6Aimin Hui7Shanghai Fosun Pharmaceutical Industrial Development, Co. Ltd., 1289 Yishan Road, Shanghai 200233, ChinaNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, ChinaNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, ChinaShanghai Fosun Pharmaceutical Industrial Development, Co. Ltd., 1289 Yishan Road, Shanghai 200233, ChinaBioNTech, An der Goldgrube 12, 55131 Mainz, GermanyBioNTech, An der Goldgrube 12, 55131 Mainz, GermanyNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, ChinaShanghai Fosun Pharmaceutical Industrial Development, Co. Ltd., 1289 Yishan Road, Shanghai 200233, ChinaBNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.https://www.mdpi.com/2076-393X/9/4/324SARS-CoV-2COVID-19mRNA vaccineefficacyimmunogenicitychallenge study
collection DOAJ
language English
format Article
sources DOAJ
author Rui-Ru Ji
Yajin Qu
Hua Zhu
Yumei Yang
Annette B. Vogel
Ugur Sahin
Chuan Qin
Aimin Hui
spellingShingle Rui-Ru Ji
Yajin Qu
Hua Zhu
Yumei Yang
Annette B. Vogel
Ugur Sahin
Chuan Qin
Aimin Hui
BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
Vaccines
SARS-CoV-2
COVID-19
mRNA vaccine
efficacy
immunogenicity
challenge study
author_facet Rui-Ru Ji
Yajin Qu
Hua Zhu
Yumei Yang
Annette B. Vogel
Ugur Sahin
Chuan Qin
Aimin Hui
author_sort Rui-Ru Ji
title BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_short BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_full BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_fullStr BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_full_unstemmed BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
title_sort bnt162b2 vaccine encoding the sars-cov-2 p2 s protects transgenic hace2 mice against covid-19
publisher MDPI AG
series Vaccines
issn 2076-393X
publishDate 2021-04-01
description BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
topic SARS-CoV-2
COVID-19
mRNA vaccine
efficacy
immunogenicity
challenge study
url https://www.mdpi.com/2076-393X/9/4/324
work_keys_str_mv AT ruiruji bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
AT yajinqu bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
AT huazhu bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
AT yumeiyang bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
AT annettebvogel bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
AT ugursahin bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
AT chuanqin bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
AT aiminhui bnt162b2vaccineencodingthesarscov2p2sprotectstransgenichace2miceagainstcovid19
_version_ 1724175794848137216

Similar Items