Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway

Nicorandil Protects the Heart from Ischemia/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K/Akt Signaling Pathway

Background/Aims: As a vasodilatory drug used to treat angina, nicorandil has been shown to induce an infarct-limiting effect in various experimental animal models of myocardial ischemia-reperfusion (IR). There are multiple mechanisms causing the IR injury, among which, the endoplasmic reticulum (ER)...

Full description

Bibliographic Details
Main Authors: Hui Wu, Ming Ye, Jun Yang, Jiawang Ding, Jian Yang, Wusong Dong, Xinan Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Apoptosis
PI3K/Akt
Nicorandil
Heart
Ischemia/Reperfusion
Endoplasmic Reticulum
Online Access:http://www.karger.com/Article/FullText/374035

Internet

http://www.karger.com/Article/FullText/374035

Similar Items