Selective adenosine A2A receptor inhibitor SCH58261 reduces oligodendrocyte loss upon brain injury in young rats

Selective adenosine A2A receptor inhibitor SCH58261 reduces oligodendrocyte loss upon brain injury in young rats

Cellular elements of maturing brain are vulnerable to insults, which lead to neurodevelopmental defects. There are no established treatments at present. Here we examined the efficacy of selective adenosine A2A receptor inhibitor SCH58261 to combat brain injury, particularly oligodendrocyte (OL) line...

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Bibliographic Details
Main Authors: Mohamed A. Al-Griw, Rabia O. Alghazeer, Nuri Awayn, Ghalia Shamlan, Areej A. Eskandrani, Afnan M. Alnajeebi, Nouf A. Babteen, Wafa S. Alansari
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Saudi Journal of Biological Sciences
Subjects:
Adenosine A2A receptor
SCH58261
Neuroprotection
Oligodendrocyte
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X20304861

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http://www.sciencedirect.com/science/article/pii/S1319562X20304861

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