Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

The mechanisms leading to NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome activation are still debated. It is well established that oligomerized NLRP3 interacts with apoptosis associated Speck-like protein containing a CARD domain (ASC) which polymerizes into filaments re...

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Bibliographic Details
Main Authors: Angélique Chevriaux, Thomas Pilot, Valentin Derangère, Harmonie Simonin, Pierre Martine, Fanny Chalmin, François Ghiringhelli, Cédric Rébé
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
NLRP3
Cathepsin B
macrophages
IL-1β
caspase-1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00167/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00167/full

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