M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway

Abstract Background Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis. Unfortunately, the mechanisms underlying these processes and the signaling factors involved are largely unknown. In this...

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Bibliographic Details
Main Authors: Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu, Bingyuan Zhang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cancer Cell International
Subjects:
Cholangiocarcinoma
M3 muscarinic acetylcholine receptors
Perineural invasion
Epithelial–mesenchymal transition
AKT
Online Access:http://link.springer.com/article/10.1186/s12935-018-0667-z

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http://link.springer.com/article/10.1186/s12935-018-0667-z

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