Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury

Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury

RationaleThe recently discovered meningeal lymphatic vessels (mLVs) have been proposed to be the missing link between the immune and the central nervous system. The role of mLVs in modulating the neuro-immune response following a traumatic brain injury (TBI), however, has not been analyzed. Parenchy...

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Bibliographic Details
Main Authors: Sara Wojciechowski, Anaïs Virenque, Maria Vihma, Barbara Galbardi, Erin Jane Rooney, Meike Hedwig Keuters, Salli Antila, Jari Koistinaho, Francesco M. Noe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
controlled cortical impact (CCI)
meningeal lymphatic vessels
CD8+ T lymphocytes
resident memory T cells
Chronic Traumatic Brain injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.559810/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.559810/full

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