Exogenous Hydrogen Sulfide Protects against Doxorubicin-Induced Inflammation and Cytotoxicity by Inhibiting p38MAPK/NFκB Pathway in H9c2 Cardiac Cells

Exogenous Hydrogen Sulfide Protects against Doxorubicin-Induced Inflammation and Cytotoxicity by Inhibiting p38MAPK/NFκB Pathway in H9c2 Cardiac Cells

Background/Aim:We have demonstrated that exogenous hydrogen sulfide (H2S) protects H9c2 cardiac cells against the doxorubicin (DOX)-induced injuries by inhibiting p38 mitogen-activated protein kinase (MAPK) pathway and that the p38 MAPK/nuclear factor-κB (NF-κB) pathway is involved...

Full description

Bibliographic Details
Main Authors: Runmin Guo, Keng Wu, Jingfu Chen, Liqiu Mo, Xiaoxiao Hua, Dongdan Zheng, Peixi Chen, Gang Chen, Wenming Xu, Jianqiang Feng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
Hydrogen sulfide
Doxorubicin
Nuclear factor-κB
Cardiotoxicity
Inflammation
p38 mitogen-activated protein kinases
Online Access:http://www.karger.com/Article/FullText/356602

Internet

http://www.karger.com/Article/FullText/356602

Similar Items