Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel

Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel

Abstract Background Mesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and clinical studies. However, they are prone to an unwanted differentiation process towards hypertrophy that limits their therapeutic efficacy. Ma...

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Bibliographic Details
Main Authors: Shahrbanoo Jahangir, David Eglin, Naomi Pötter, Mojtaba Khozaei Ravari, Martin J. Stoddart, Ali Samadikuchaksaraei, Mauro Alini, Mohammadreza Baghaban Eslaminejad, Majid Safa
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Stem Cell Research & Therapy
Subjects:
Chondrocyte hypertrophy
Platelet lysate
MMP-13 inhibitor
Small molecules
And mechanical properties
Online Access:http://link.springer.com/article/10.1186/s13287-020-01930-1

Internet

http://link.springer.com/article/10.1186/s13287-020-01930-1

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