Oral administration of recombinant Bacillus subtilis spores expressing mutant staphylococcal enterotoxin B provides potent protection against lethal enterotoxin challenge

Oral administration of recombinant Bacillus subtilis spores expressing mutant staphylococcal enterotoxin B provides potent protection against lethal enterotoxin challenge

Abstract Pathogenicity of Staphylococcus aureus is induced by staphylococcal enterotoxin B (SEB). A mutant form of SEB (mSEB) is immunogenic as well as less toxic. Recombinant mSEB and SEB were expressed in pET28a prokaryotic plasmids. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels...

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Bibliographic Details
Main Authors: Zhile Xiong, Jialiang Mai, Fei Li, Bingshao Liang, Shuwen Yao, Zhuwei Liang, Chao Zhang, Fei Gao, Xiaolan Ai, Jielin Wang, Yan Long, Min Yang, Sitang Gong, Zhenwen Zhou
Format: Article
Language:English
Published: SpringerOpen 2020-12-01
Series:AMB Express
Subjects:
Staphylococcus aureus
Staphylococcal enterotoxin B
Vaccination
Bacillus subtilis
Online Access:https://doi.org/10.1186/s13568-020-01152-x

Internet

https://doi.org/10.1186/s13568-020-01152-x

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