PLS3 Overexpression Delays Ataxia in Chp1 Mutant Mice

PLS3 Overexpression Delays Ataxia in Chp1 Mutant Mice

Many neurodegenerative disorders share common pathogenic pathways such as endocytic defects, Ca2+ misregulation and defects in actin dynamics. Factors acting on these shared pathways are highly interesting as a therapeutic target. Plastin 3 (PLS3), a proven protective modifier of spinal muscular atr...

Full description

Bibliographic Details
Main Authors: Eva Janzen, Lisa Wolff, Natalia Mendoza-Ferreira, Kristina Hupperich, Andrea Delle Vedove, Seyyedmohsen Hosseinibarkooie, Min Jeong Kye, Brunhilde Wirth
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
plastin 3 (PLS3)
calcineurin like EF-hand protein 1 (CHP1)
Na+/H+ exchanger (NHE1)
ataxia
neurodegeneration
modifier
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00993/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00993/full

Similar Items