LncRNA nuclear‐enriched abundant transcript 1 shuttled by prostate cancer cells‐secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR‐205‐5p/runt‐related transcription factor 2/splicing factor proline‐ and glutamine‐rich/polypyrimidine tract‐binding protein 2 axis

LncRNA nuclear‐enriched abundant transcript 1 shuttled by prostate cancer cells‐secreted exosomes initiates osteoblastic phenotypes in the bone metastatic microenvironment via miR‐205‐5p/runt‐related transcription factor 2/splicing factor proline‐ and glutamine‐rich/polypyrimidine tract‐binding protein 2 axis

Abstract Prostate cancer (PCa) patients commonly present with osteoblastic‐type bone metastasis. Exosomes derived from tumor cells possess biological significance and can mediate intercellular communication in the tumor microenvironment. Long noncoding RNA (lncRNA) nuclear‐enriched abundant transcri...

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Bibliographic Details
Main Authors: Chengqiang Mo, Bin Huang, Jintao Zhuang, Shuangjian Jiang, Shengjie Guo, Xiaopeng Mao
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Clinical and Translational Medicine
Subjects:
extracellular vesicles
mesenchymal stem cells
NEAT1
osteogenic differentiation
prostate cancer
RUNX2
Online Access:https://doi.org/10.1002/ctm2.493

Internet

https://doi.org/10.1002/ctm2.493

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