Improved immunological tolerance following combination therapy with CTLA-4/Ig and AAV-mediated PD-L1/2 muscle gene transfer

Improved immunological tolerance following combination therapy with CTLA-4/Ig and AAV-mediated PD-L1/2 muscle gene transfer

Initially thought as being non-immunogenic, recombinant AAVs (rAAV) have emerged as efficient vector candidates for treating monogenic diseases. It is now clear however that they induce potent immune responses against transgene products which can lead to destruction of transduced cells. Therefore, d...

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Bibliographic Details
Main Authors: Sahil eAdriouch, Emilie eFranck, Laurent eDrouot, Carole eBonneau, Nelly eJolinon, Anna eSalvetti, Olivier eBoyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-09-01
Series:Frontiers in Microbiology
Subjects:
Gene Therapy
CTLA-4
costimulation
immunological tolerance
AAV vectors
PD-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00199/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00199/full

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