A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxe...

Full description

Bibliographic Details
Main Authors: Yang Han, Na Liang, Pengfei Yan, Yoshiaki Kawashima, Fude Cui, Shaoping Sun
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Polymers
Subjects:
chitosan
cholesterol
micelles
mpeg
redox-responsive
Online Access:https://www.mdpi.com/2073-4360/12/2/380
id doaj-6593e3d99f434041ac15ce4872ed02b4
record_format Article
spelling doaj-6593e3d99f434041ac15ce4872ed02b42020-11-25T02:03:24ZengMDPI AGPolymers2073-43602020-02-0112238010.3390/polym12020380polym12020380A Chitosan-Based Micellar System as Nanocarrier For the Delivery of PaclitaxelYang Han0Na Liang1Pengfei Yan2Yoshiaki Kawashima3Fude Cui4Shaoping Sun5Department of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, ChinaCollege of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, ChinaDepartment of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, ChinaDepartment of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, JapanSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutical Engineering, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, ChinaIn this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX.https://www.mdpi.com/2073-4360/12/2/380chitosancholesterolmicellesmpegredox-responsive
collection DOAJ
language English
format Article
sources DOAJ
author Yang Han
Na Liang
Pengfei Yan
Yoshiaki Kawashima
Fude Cui
Shaoping Sun
spellingShingle Yang Han
Na Liang
Pengfei Yan
Yoshiaki Kawashima
Fude Cui
Shaoping Sun
A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
Polymers
chitosan
cholesterol
micelles
mpeg
redox-responsive
author_facet Yang Han
Na Liang
Pengfei Yan
Yoshiaki Kawashima
Fude Cui
Shaoping Sun
author_sort Yang Han
title A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_short A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_full A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_fullStr A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_full_unstemmed A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
title_sort chitosan-based micellar system as nanocarrier for the delivery of paclitaxel
publisher MDPI AG
series Polymers
issn 2073-4360
publishDate 2020-02-01
description In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX.
topic chitosan
cholesterol
micelles
mpeg
redox-responsive
url https://www.mdpi.com/2073-4360/12/2/380
work_keys_str_mv AT yanghan achitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT naliang achitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT pengfeiyan achitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT yoshiakikawashima achitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT fudecui achitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT shaopingsun achitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT yanghan chitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT naliang chitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT pengfeiyan chitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT yoshiakikawashima chitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT fudecui chitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
AT shaopingsun chitosanbasedmicellarsystemasnanocarrierforthedeliveryofpaclitaxel
_version_ 1724948467829178368

Similar Items