Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors

Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors

Genomic instability is a hallmark of cancer related to DNA damage response (DDR) deficiencies, offering vulnerabilities for targeted treatment. Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) interfere with the efficient repair of DNA damage, particularly in tumors with existing defects in DN...

Full description

Bibliographic Details
Main Authors: Florent Peyraud, Antoine Italiano
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
PARP inhibitor
DNA damage response
immunotherapy
immune checkpoint inhibitor
PD-1
PD-L1
Online Access:https://www.mdpi.com/2072-6694/12/6/1502

Internet

https://www.mdpi.com/2072-6694/12/6/1502

Similar Items