Kaempferol Improves Lung Ischemia-Reperfusion Injury via Antiinflammation and Antioxidative Stress Regulated by SIRT1/HMGB1/NF-κB Axis

Kaempferol Improves Lung Ischemia-Reperfusion Injury via Antiinflammation and Antioxidative Stress Regulated by SIRT1/HMGB1/NF-κB Axis

Trauma, organ transplantation, and thromboembolism are the main causes of lung ischemia-reperfusion injury (LIRI), and new therapies and drugs are urgent to relieve LIRI. In preliminary experiment, authors found that kaempferol could improve LIRI in rats, and the current study further explored its p...

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Bibliographic Details
Main Authors: Chunli Yang, Wenkai Yang, Zhaohui He, Huiwei He, Xiaogang Yang, Yuanhua Lu, Hongbo Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
kaempferol
lung ischemia-reperfusion injury
inflammation
oxidative stress
SIRT1
HMGB1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01635/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01635/full

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