Live Attenuated Influenza Vaccine contains Substantial and Unexpected Amounts of Defective Viral Genomic RNA

The live attenuated influenza vaccine FluMist® was withdrawn in the USA by the Centers for Disease Control and Prevention after its failure to provide adequate protective immunity during 2013–2016. The vaccine uses attenuated core type A and type B viruses, reconfigured each year to express the two...

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Bibliographic Details
Main Authors: Philip S. Gould, Andrew J. Easton, Nigel J. Dimmock
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/9/10/269