Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

PSD-95 MAGUK family scaffold proteins are multi-domain organisers of synaptic transmission that contain three PDZ domains followed by an SH3-GK domain tandem. This domain architecture allows coordinated assembly of protein complexes composed of neurotransmitter receptors, synaptic adhesion molecules...

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Bibliographic Details
Main Authors: Nils Rademacher, Benno Kuropka, Stella-Amrei Kunde, Markus C Wahl, Christian Freund, Sarah A Shoichet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
postsynaptic density
protein complex regulation
MAGUK
heterotrimeric G protein subunit
bimolecular fluorescence complementation
quantitative mass spectrometry
Online Access:https://elifesciences.org/articles/41299

Internet

https://elifesciences.org/articles/41299

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