Transmission-clearance trade-offs indicate that dengue virulence evolution depends on epidemiological context

Theory predicts that pathogens will evolve towards intermediate virulence, yet the necessary trade-offs invoked by this theory have rarely been demonstrated empirically. Here, the authors show that dengue virus dynamics exhibit a trade-off between transmission and clearance rates.

Bibliographic Details
Main Authors: Rotem Ben-Shachar, Katia Koelle
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04595-w