Manganese Superoxide Dismutase Overexpression Attenuates MPTP Toxicity

Manganese Superoxide Dismutase Overexpression Attenuates MPTP Toxicity

There is substantial evidence implicating mitochondrial dysfunction and free radical generation in the neurotoxicity of MPTP. Manganese superoxide dismutase (MnSOD) is the primary antioxidant enzyme protecting against superoxide radicals produced within mitochondria. Overexpression of human MnSOD in...

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Bibliographic Details
Main Authors: Peter Klivenyi, Daret St. Clair, Marike Wermer, Hsin-Chuan Yen, Terry Oberley, Lichuan Yang, M.Flint Beal
Format: Article
Language:English
Published: Elsevier 1998-10-01
Series:Neurobiology of Disease
Subjects:
MPTP
Parkinson's disease
free radicals
oxidative damage
superoxide dismutase.
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996198901917

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http://www.sciencedirect.com/science/article/pii/S0969996198901917

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