Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4<sup>CRBN</sup> Protein Degradation Axis
Cereblon (CRBN), a primary target of immune-modulatory imide drugs (IMiDs), functions as a substrate receptor in the CUL4-RBX1-DDB1-CRBN (known as CRL4<sup>CRBN</sup>) E3 ubiquitin ligase complex. Binding of IMiDs to CRBN redirects the CRL4<sup>CRBN</sup> E3 ubiquitin ligase...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/6/512 |