AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia.

AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia.

Achromatopsia is a rare autosomal recessive disorder which shows color blindness, severely impaired visual acuity, and extreme sensitivity to bright light. Mutations in the alpha subunits of the cone cyclic nucleotide-gated channels (CNGA3) are responsible for about 1/4 of achromatopsia in the U.S....

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Bibliographic Details
Main Authors: Ji-jing Pang, Wen-Tao Deng, Xufeng Dai, Bo Lei, Drew Everhart, Yumiko Umino, Jie Li, Keqing Zhang, Song Mao, Sanford L Boye, Li Liu, Vince A Chiodo, Xuan Liu, Wei Shi, Ye Tao, Bo Chang, William W Hauswirth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3324465?pdf=render

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http://europepmc.org/articles/PMC3324465?pdf=render

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